Prospective, Multi-center Randomized Intermediate Biomarker Study of Oral Contraceptive vs. Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome

Women with Lynch syndrome have a 40–60% lifetime risk for developing endometrial cancer, a cancer associated with estrogen imbalance. The molecular basis for endometrial-specific tumorigenesis is unclear. Progestins inhibit estrogen-driven proliferation, and epidemiologic studies have demonstrated t...

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Bibliografiske detaljer
Main Authors: Lu, Karen H., Loose, David S., Yates, Melinda S., Nogueras-Gonzalez, Graciela M., Munsell, Mark F., Chen, Lee-may, Lynch, Henry, Cornelison, Terri, Boyd-Rogers, Stephanie, Rubin, Mary, Daniels, Molly S., Conrad, Peggy, Milbourne, Andrea, Gershenson, David M., Broaddus, Russell R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737517/
https://ncbi.nlm.nih.gov/pubmed/23639481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-13-0020
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