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Cas3 stimulates runaway replication of a ColE1 plasmid in Escherichia coli and antagonises RNaseHI
Cas3 nuclease-helicase is part of CRISPR immunity systems in many bacteria and archaea. In type I CRISPR, Cas3 nuclease degrades invader DNA that has been base-paired to crRNA as an R-loop within a “Cascade” complex. An R-loop is a DNA-RNA hybrid that includes a displaced single-strand DNA loop. Pur...
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| Main Authors: | , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Landes Bioscience
2013
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3737335/ https://ncbi.nlm.nih.gov/pubmed/23406879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.23876 |
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