Integrated Genotypic Analysis of Hedgehog-Related Genes Identifies Subgroups of Keratocystic Odontogenic Tumor with Distinct Clinicopathological Features

Keratocystic odontogenic tumor (KCOT) arises as part of Gorlin syndrome (GS) or as a sporadic lesion. Gene mutations and loss of heterozygosity (LOH) of the hedgehog receptor PTCH1 plays an essential role in the pathogenesis of KCOT. However, some KCOT cases lack evidence for gene alteration of PTCH...

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Detalhes bibliográficos
Main Authors: Shimada, Yasuyuki, Katsube, Ken-ichi, Kabasawa, Yuji, Morita, Kei-ichi, Omura, Ken, Yamaguchi, Akira, Sakamoto, Kei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737235/
https://ncbi.nlm.nih.gov/pubmed/23951062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070995
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