Mechanical Stretch Increases MMP-2 Production in Vascular Smooth Muscle Cells via Activation of PDGFR-β/Akt Signaling Pathway

Increased blood pressure, leading to mechanical stress on vascular smooth muscle cells (VSMC), is a known risk factor for vascular remodeling via increased activity of matrix metalloproteinase (MMP) within the vascular wall. This study aimed to identify cell surface mechanoreceptors and intracellula...

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Bibliographische Detailangaben
Hauptverfasser: Seo, Kyo Won, Lee, Seung Jin, Kim, Yun Hak, Bae, Jin Ung, Park, So Youn, Bae, Sun Sik, Kim, Chi Dae
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737227/
https://ncbi.nlm.nih.gov/pubmed/23950935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070437
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