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Single-Molecule Kinetics Reveal Cation-Promoted DNA Duplex Formation Through Ordering of Single-Stranded Helices

In this work, the kinetics of short, fully complementary oligonucleotides are investigated at the single-molecule level. Constructs 6–9 bp in length exhibit single exponential kinetics over 2 orders of magnitude time for both forward (k(on), association) and reverse (k(off), dissociation) processes....

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Autori principali: Dupuis, Nicholas F., Holmstrom, Erik D., Nesbitt, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736743/
https://ncbi.nlm.nih.gov/pubmed/23931323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.05.061
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