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Laminin β2 Gene Missense Mutation Produces Endoplasmic Reticulum Stress in Podocytes

Mutations in the laminin β2 gene (LAMB2) cause Pierson syndrome, a severe congenital nephrotic syndrome with ocular and neurologic defects. LAMB2 is a component of the laminin-521 (α5β2γ1) trimer, an important constituent of the glomerular basement membrane (GBM). The C321R-LAMB2 missense mutation l...

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Detalhes bibliográficos
Main Authors: Chen, Ying Maggie, Zhou, Yuefang, Go, Gloriosa, Marmerstein, Joseph T., Kikkawa, Yamato, Miner, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736718/
https://ncbi.nlm.nih.gov/pubmed/23723427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012121149
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