Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

Type 2 diabetes is characterized by insulin resistance and pancreatic β cell dysfunction, the latter possibly caused by a defect in insulin signaling in β cells. Inhibition of class IA phosphatidylinositol 3-kinase (PI3K), using a mouse model lacking the pik3r1 gene specifically in β cells and the p...

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Main Authors: Kaneko, Kazuma, Ueki, Kohjiro, Takahashi, Noriko, Hashimoto, Shinji, Okamoto, Masayuki, Awazawa, Motoharu, Okazaki, Yukiko, Ohsugi, Mitsuru, Inabe, Kazunori, Umehara, Toshihiro, Yoshida, Masashi, Kakei, Masafumi, Kitamura, Tadahiro, Luo, Ji, Kulkarni, Rohit N., Kahn, C. Ronald, Kasai, Haruo, Cantley, Lewis C., Kadowaki, Takashi
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736578/
https://ncbi.nlm.nih.gov/pubmed/21109194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.005
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