Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects

BACKGROUND: Here, we aimed to investigate the pharmacokinetics of abacavir and carbovir triphosphate (CBV-TP) with darunavir/ritonavir 900/100 mg once daily or raltegravir 400 mg twice daily. METHODS: HIV-infected subjects on abacavir (600 mg once daily) underwent steady-state pharmacokinetic assess...

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Main Authors: Jackson, Akil, Moyle, Graeme, Dickinson, Laura, Back, David, Khoo, Saye, Taylor, Jessica, Gedela, Keerti, Abongomera, George, Gazzard, Brian, Boffito, Marta
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736319/
https://ncbi.nlm.nih.gov/pubmed/22267465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP1910
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