A Common Mutation in DEFB126 Causes Impaired Sperm Function and Subfertility

A glycosylated polypeptide, β-defensin 126 (DEFB126), derived from the epididymis and adsorbed onto the sperm surface, has been implicated in immunoprotection and efficient movement of sperm in mucosal fluids of the female reproductive tract. Here, we report a sequence variant in DEFB126 that has a...

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Hauptverfasser: Tollner, Theodore L., Venners, Scott A., Hollox, Edward J., Yudin, Ashley I., Liu, Xue, Tang, Genfu, Xing, Houxun, Kays, Robert J., Lau, Tsang, Overstreet, James W., Xu, Xiping, Bevins, Charles L., Cherr, Gary N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736313/
https://ncbi.nlm.nih.gov/pubmed/21775668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002289
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