Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial

Safety and pharmacokinetics (PK) of recombinant von Willebrand factor (rVWF) combined at a fixed ratio with recombinant factor VIII (rFVIII) were investigated in 32 subjects with type 3 or severe type 1 von Willebrand disease (VWD) in a prospective phase 1, multicenter, randomized clinical trial. rV...

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Detalhes bibliográficos
Main Authors: Mannucci, Pier Mannuccio, Kempton, Christine, Millar, Carolyn, Romond, Edward, Shapiro, Amy, Birschmann, Ingvild, Ragni, Margaret V., Gill, Joan Cox, Yee, Thynn Thynn, Klamroth, Robert, Wong, Wing-Yen, Chapman, Miranda, Engl, Werner, Turecek, Peter L., Suiter, Tobias M., Ewenstein, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736194/
https://ncbi.nlm.nih.gov/pubmed/23777763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-479527
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