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Induction of antiviral genes by the tumor microenvironment confers resistance to virotherapy
Oncolytic viruses obliterate tumor cells in tissue culture but not against the same tumors in vivo. We report that macrophages can induce a powerfully protective antiviral state in ovarian and breast tumors, rendering them resistant to oncolytic virotherapy. These tumors have activated JAK/STAT path...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3736178/ https://ncbi.nlm.nih.gov/pubmed/23921465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02375 |
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