Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate

Chronic exposure of skeletal muscle to saturated fatty acids, such as palmitate (C16:0), enhances proinflammatory IKK-NFκB signaling by a mechanism involving the MAP kinase (Raf-MEK-ERK) pathway. Raf activation can be induced by its dissociation from the Raf-kinase inhibitor protein (RKIP) by diacyl...

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Detalhes bibliográficos
Main Authors: Macrae, Katherine, Stretton, Clare, Lipina, Christopher, Blachnio-Zabielska, Agnieszka, Baranowski, Marcin, Gorski, Jan, Marley, Anna, Hundal, Harinder S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735935/
https://ncbi.nlm.nih.gov/pubmed/23833248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M036996
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