Proprotein Convertase Subtilisin/Kexin Type 3 Promotes Adipose Tissue-Driven Macrophage Chemotaxis and Is Increased in Obesity

BACKGROUND: Matrix metalloproteinase (MMP)-dependent extracellular matrix (ECM) remodeling is a key feature in cardiometabolic syndrome-associated adipogenesis and atherosclerosis. Activation of membrane-tethered (MT) 1-MMP depends on furin (PCSK3). However, the regulation and function of the natura...

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Autors principals: Kappert, Kai, Meyborg, Heike, Fritzsche, Jan, Urban, Daniel, Krüger, Janine, Wellnhofer, Ernst, Kintscher, Ulrich, Fleck, Eckart, Stawowy, Philipp
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735592/
https://ncbi.nlm.nih.gov/pubmed/23936445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070542
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