Clade-Specific Virulence Patterns of Mycobacterium tuberculosis Complex Strains in Human Primary Macrophages and Aerogenically Infected Mice

In infection experiments with genetically distinct Mycobacterium tuberculosis complex (MTBC) strains, we identified clade-specific virulence patterns in human primary macrophages and in mice infected by the aerosol route, both reflecting relevant model systems. Exclusively human-adapted M. tuberculo...

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Main Authors: Reiling, Norbert, Homolka, Susanne, Walter, Kerstin, Brandenburg, Julius, Niwinski, Lisa, Ernst, Martin, Herzmann, Christian, Lange, Christoph, Diel, Roland, Ehlers, Stefan, Niemann, Stefan
Format: Artigo
Jezik:Inglês
Izdano: American Society of Microbiology 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735190/
https://ncbi.nlm.nih.gov/pubmed/23900170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00250-13
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