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Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: a novel experimental model of pharmacoresistant epilepsy
PURPOSE: Kindling is a well established model of secondarily generalized partial seizures that is widely employed in the search for novel antiseizure drugs. During the kindling and post-kindling acquisition phase, an active process of neuronal remodeling occurs. We tested the hypothesis that exposur...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3735163/ https://ncbi.nlm.nih.gov/pubmed/23750799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12234 |
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