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Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior

The acid-sensing ion channel 1a (ASIC1a) is abundantly expressed in the amygdala complex and other brain regions associated with fear. Studies of mice with a disrupted ASIC1 gene suggested that ASIC1a may contribute to learned fear. To test this hypothesis, we generated mice overexpressing human ASI...

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Autors principals: Wemmie, John A., Coryell, Matthew W., Askwith, Candice C., Lamani, Ejvis, Leonard, A. Soren, Sigmund, Curt D., Welsh, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC373512/
https://ncbi.nlm.nih.gov/pubmed/14988500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308753101
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