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The herpes simplex virus 1 U(L)41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific

In cells infected with herpes simplex virus 1, the RNA encoded by the stress-inducible immediate early response gene IEX-1 was up-regulated immediately after infection. However, the accumulated RNA was degraded 3′-5′, and the protein was detectable only at very early times after infection. The degra...

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Autors principals: Esclatine, Audrey, Taddeo, Brunella, Evans, Linton, Roizman, Bernard
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC373509/
https://ncbi.nlm.nih.gov/pubmed/14993598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400354101
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