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New sample preparation approach for mass spectrometry-based profiling of plasma results in improved coverage of metabolome

Sample preparation remains a challenge in untargeted metabolomics studies and no method currently results in complete extraction of all metabolite classes in human plasma. Because a large variety of molecules, with vast differences in dynamic range, could be involved in human disease, there is an ur...

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Detalhes bibliográficos
Main Authors: Yang, Yanhui, Cruickshank, Charmion, Armstrong, Michael, Mahaffey, Spencer, Reisdorph, Rick, Reisdorph, Nichole
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734953/
https://ncbi.nlm.nih.gov/pubmed/23672979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2013.04.030
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