Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

The mammalian F-box protein Fbw7 and its Caenorhabditis elegans counterpart Sel-10 have been implicated in the ubiquitin-mediated turnover of cyclin E as well as the Notch/Lin-12 family of transcriptional activators. Both unregulated Notch and cyclin E promote tumorigenesis, and inactivating mutatio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Tetzlaff, Michael T., Yu, Wei, Li, Mamie, Zhang, Pumin, Finegold, Milton, Mahon, Kathleen, Harper, J. Wade, Schwartz, Robert J., Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373463/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14766969/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307875101
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