Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms

Circadian rhythms can be entrained by a light-dark (LD) cycle and can also be reset pharmacologically, for example, by the CK1δ/ε inhibitor PF-670462. Here, we determine how these two independent signals affect circadian timekeeping from the molecular to the behavioral level. By developing a systems...

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Autors principals: Kim, J K, Forger, D B, Marconi, M, Wood, D, Doran, A, Wager, T, Chang, C, Walton, K M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734602/
https://ncbi.nlm.nih.gov/pubmed/23863866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.34
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