STAT6 promotes bi-directional modulation of PKM2 in liver and adipose inflammatory cells in Rosiglitazone-treated mice

STAT6 interacts with PPARγ to elicit macrophage polarization towards an anti-inflammatory, insulin-sensitizing phenotype. Mice deficient in STAT6 display liver lipid accumulation (hepatosteatosis). Rosiglitazone (RSG), a PPARγ agonist, ameliorates hepatosteatosis and enhances insulin sensitivity. To...

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Sonraí Bibleagrafaíochta
Main Authors: Sajic, Tatjana, Hainard, Alexandre, Scherl, Alexander, Wohlwend, Annelise, Negro, Francesco, Sanchez, Jean-Charles, Szanto, Ildiko
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734444/
https://ncbi.nlm.nih.gov/pubmed/23917405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02350
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