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An Intronic miRNA Regulates Expression of the Human Endothelial Nitric Oxide Synthase Gene and Proliferation of Endothelial Cells by a Mechanism Related to the Transcription Factor SP-1

OBJECTIVE: This study was to investigate the molecular mechanisms underlying the 27nt-miRNA-mediated regulation of expression of the endothelial nitric oxide synthase (eNOS) gene. METHODS: Cell lines overexpressing 27nt-miRNA or its mutant were established by transfecting the miRNA expression vector...

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Autori principali: Yan, Limei, Kang, Min, Qin, Zhengqi, Zhang, Wenyu, Li, Yumei, Ou, Hesheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734264/
https://ncbi.nlm.nih.gov/pubmed/23940615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070658
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