Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation

BACKGROUND: Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland during involution and by radiation. While TGFβ normally has a tumour suppressor role, prolonged exposure to TGFβ can induce an oncogenic epithelial to mesenchymal transition (EMT) program in permissive c...

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Autori principali: Dunphy, Karen A, Seo, Jae-Hong, Kim, Daniel J, Roberts, Amy L, Tao, Luwei, DiRenzo, James, Balboni, Amanda L, Crisi, Giovanna M, Hagen, Mary J, Chandrasekaran, Thiruppavai, Gauger, Kelly J, Schneider, Sallie Smith, Jerry, D Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Primary Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733955/
https://ncbi.nlm.nih.gov/pubmed/23883065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-13-74
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