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Insights into the N-Sulfation Mechanism: Molecular Dynamics Simulations of the N-Sulfotransferase Domain of Ndst1 and Mutants

Sulfation patterns along glycosaminoglycan (GAG) chains dictate their functional role. The N-deacetylase N-sulfotransferase family (NDST) catalyzes the initial downstream modification of heparan sulfate and heparin chains by removing acetyl groups from subsets of N-acetylglucosamine units and, subse...

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Detalhes bibliográficos
Main Authors: Gesteira, Tarsis F., Pol-Fachin, Laércio, Coulson-Thomas, Vivien Jane, Lima, Marcelo A., Verli, Hugo, Nader, Helena B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733922/
https://ncbi.nlm.nih.gov/pubmed/23940657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070880
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