2′-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo

Synthesis and antisense activity of oligonucleotides modified with 2′-O-[2-[(N,N-dimethylamino)oxy] ethyl] (2′-O-DMAOE) are described. The 2′-O-DMAOE-modified oligonucleotides showed superior metabolic stability in mice. The phosphorothioate oligonucleotide ‘gapmers’, with 2′-O-DMAOE- modified nucle...

詳細記述

書誌詳細

出版年:	Nucleic Acids Res
主要な著者:	Prakash, Thazha P., Johnston, Joseph F., Graham, Mark J., Condon, Thomas P., Manoharan, Muthiah
フォーマット:	Artigo
言語:	Inglês
出版事項:	Oxford University Press 2004
主題:	Articles
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373344/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14762210/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh220
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