SAR-Based Optimization of a 4-Quinoline Carboxylic Acid Analogue with Potent Antiviral Activity

[Image: see text] It is established that drugs targeting viral proteins are at risk of generating resistant strains. However, drugs targeting host factors can potentially avoid this problem. Herein, we report structure–activity relationship studies leading to the discovery of a very potent lead comp...

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Bibliographic Details
Main Authors: Das, Priyabrata, Deng, Xiaoyi, Zhang, Liang, Roth, Michael G., Fontoura, Beatriz M. A., Phillips, Margaret A., De Brabander, Jef K.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2013
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733392/
https://ncbi.nlm.nih.gov/pubmed/23930152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300464h
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