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Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate
The interaction of the hepatitis C virus (HCV) RNA-dependent RNA polymerase with RNA substrate is incompletely defined. We have characterized the activities of the HCV NS5B polymerase, modified by different deletions and affinity tags, with a routinely used homopolymeric substrate, and established a...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC373316/ https://ncbi.nlm.nih.gov/pubmed/14739234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh160 |
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