Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with red...

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Detalhes bibliográficos
Main Authors: Song, Jian, Lokmic, Zerina, Lämmermann, Tim, Rolf, Julia, Wu, Chuan, Zhang, Xueli, Hallmann, Rupert, Hannocks, Melanie-Jane, Horn, Nathalie, Ruegg, Markus A., Sonnenberg, Arnoud, Georges-Labouesse, Elisabeth, Winkler, Thomas H., Kearney, John F., Cardell, Susanna, Sorokin, Lydia
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732919/
https://ncbi.nlm.nih.gov/pubmed/23847204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218131110
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