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The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe

The abasic (AP) sites, the major mutagenic and cytotoxic genomic lesions, induced directly by oxidative stress and indirectly after excision of damaged bases by DNA glycosylases, are repaired by AP-endonucleases (APEs). Among two APEs in Saccharomyces cerevisiae, Apn1 provides the major APE activity...

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Udgivet i:Nucleic Acids Res
Principais autores: Ribar, Balazs, Izumi, Tadahide, Mitra, Sankar
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2004
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373264/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14704348/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh151
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