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Novel recombinant human B7-H4 antibodies overcome tumoral immune escape to potentiate T cell anti-tumor responses
B7-H4 (VTCN1, B7x ,B7s) is a ligand for inhibitory co-receptors on T cells implicated in antigenic tolerization. B7-H4 is expressed by tumor cells and tumor-associated macrophages (TAMs), but its potential contributions to tumoral immune escape and therapeutic targeting have been little studied. To...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3732560/ https://ncbi.nlm.nih.gov/pubmed/23722540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3457 |
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