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Loss of MAGT1 abrogates a Mg(2+) flux required for T cell signaling and leads to a novel human primary immunodeficiency
Although Mg(2+) has a well-recognized role as an essential cofactor for all ATP-binding enzymes, its role as a signaling ion like Ca(2+) has been controversial. A requirement for Mg(2+) for optimal T lymphocyte stimulation was demonstrated more than 30 years ago, but the mechanism of its synergistic...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3732466/ https://ncbi.nlm.nih.gov/pubmed/21983175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1684/mrh.2011.0286 |
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