Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data

BACKGROUND: The gold standard endpoint in clinical trials of chemotherapy and radiotherapy for lung cancer is overall survival. Although reliable and simple to measure, this endpoint takes years to observe. Surrogate endpoints that would enable earlier assessments of treatment effects would be usefu...

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Hauptverfasser: Mauguen, Audrey, Pignon, Jean-Pierre, Burdett, Sarah, Domerg, Caroline, Fisher, David, Paulus, Rebecca, Mandrekar, Samithra J, Belani, Chandra P, Shepherd, Frances A, Eisen, Tim, Pang, Herbert, Collette, Laurence, Sause, William T, Dahlberg, Suzanne E, Crawford, Jeffrey, O'Brien, Mary, Schild, Steven E, Parmar, Mahesh, Tierney, Jayne F, Pechoux, Cécile Le, Michiels, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lancet Pub. Group 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732017/
https://ncbi.nlm.nih.gov/pubmed/23680111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(13)70158-X
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