Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation()

Foxp3, a winged-helix family transcription factor, serves as the master switch for CD4(+) regulatory T cells (Treg). We identified a unique and evolutionarily conserved CpG-rich island of the Foxp3 nonintronic upstream enhancer and discovered that a specific site within it was unmethylated in natura...

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Hlavní autoři: Lal, Girdhari, Zhang, Nan, van der Touw, William, Ding, Yaozhong, Ju, Wenjun, Bottinger, Erwin P., Reid, St. Patrick, Levy, David E., Bromberg, Jonathan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731994/
https://ncbi.nlm.nih.gov/pubmed/19109157
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