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Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

Cerebral malaria (CM) is a major cause of mortality in African children and the mechanisms underlying its development, namely how malaria-infected erythrocytes (IEs) cause disease and why the brain is preferentially affected, remain unclear. Brain microhemorrhages in CM suggest a clotting disorder,...

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Main Authors: Moxon, Christopher A., Wassmer, Samuel C., Milner, Danny A., Chisala, Ngawina V., Taylor, Terrie E., Seydel, Karl B., Molyneux, Malcolm E., Faragher, Brian, Esmon, Charles T., Downey, Colin, Toh, Cheng-Hock, Craig, Alister G., Heyderman, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731936/
https://ncbi.nlm.nih.gov/pubmed/23741007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-490219
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