Malaria Parasite-Synthesized Heme Is Essential in the Mosquito and Liver Stages and Complements Host Heme in the Blood Stages of Infection

Heme metabolism is central to malaria parasite biology. The parasite acquires heme from host hemoglobin in the intraerythrocytic stages and stores it as hemozoin to prevent free heme toxicity. The parasite can also synthesize heme de novo, and all the enzymes in the pathway are characterized. To stu...

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Autors principals: Nagaraj, Viswanathan Arun, Sundaram, Balamurugan, Varadarajan, Nandan Mysore, Subramani, Pradeep Annamalai, Kalappa, Devaiah Monnanda, Ghosh, Susanta Kumar, Padmanaban, Govindarajan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731253/
https://ncbi.nlm.nih.gov/pubmed/23935500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003522
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