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Beyond the intention to treat in comparative effectiveness research

BACKGROUND: The intention-to-treat (ITT) comparison is the primary, if not the only, analytic approach of many randomized clinical trials (RCTs). PURPOSE: To review the shortcomings of ITT analyses, and of “as treated” and “per protocol” analyses as commonly implemented, with an emphasis on problems...

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Detalhes bibliográficos
Main Authors: Hernán, Miguel A., Hernández-Díaz, Sonia
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731071/
https://ncbi.nlm.nih.gov/pubmed/21948059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774511420743
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