The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis

BACKGROUND: A long non-coding RNA (lncRNA), nuclear-enriched abundant transcript 1_2 (NEAT1_2), constitutes nuclear bodies known as “paraspeckles”. Mutations of RNA binding proteins, including TAR DNA-binding protein-43 (TDP-43) and fused in sarcoma/translocated in liposarcoma (FUS/TLS), have been d...

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Main Authors: Nishimoto, Yoshinori, Nakagawa, Shinichi, Hirose, Tetsuro, Okano, Hirotaka James, Takao, Masaki, Shibata, Shinsuke, Suyama, Satoshi, Kuwako, Ken-ichiro, Imai, Takao, Murayama, Shigeo, Suzuki, Norihiro, Okano, Hideyuki
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729541/
https://ncbi.nlm.nih.gov/pubmed/23835137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-6-31
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