Impact of Genetic Heterogeneity in Polymerase of Hepatitis B Virus on Dynamics of Viral Load and Hepatitis B Progression

OBJECTIVE: The hepatitis B virus (HBV)-polymerase region overlaps pre-S/S genes with high epitope density and plays an essential role in viral replication. We investigated whether genetic variation in the polymerase region determined long-term dynamics of viral load and the risk of hepatitis B progr...

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Autors principals: Huang, Chi-Jung, Wu, Chih-Feng, Lan, Chia-Ying, Sung, Feng-Yu, Lin, Chih-Lin, Liu, Chun-Jen, Liu, Hsin-Fu, Yu, Ming-Whei
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728348/
https://ncbi.nlm.nih.gov/pubmed/23936156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070169
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