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The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch
Despite the complexity and variety of biological oscillators, their core design invariably includes an essential negative feedback loop. In the Xenopus laevis embryonic cell cycle oscillator, this loop consists of the kinase cyclin B-Cdk1 and the ubiquitin ligase APC/C(Cdc20); active Cdk1 activates...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3728279/ https://ncbi.nlm.nih.gov/pubmed/23624406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2737 |
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