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PTEN Plasticity - How the Taming of a Lethal Gene Can Go too Far
PTEN loss drives many cancers and recent genetic studies reveal that often PTEN is antagonised at the protein level without alteration of DNA or RNA expression. This scenario can already cause malignancy since PTEN is haploinsufficient. We here review normally occurring mechanisms of PTEN protein re...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3728179/ https://ncbi.nlm.nih.gov/pubmed/23578748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2013.03.003 |
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