Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

Lipid droplets (LDs) store metabolic energy and membrane lipid precursors. With excess metabolic energy, cells synthesize triacylglycerol (TG) and form LDs that grow dramatically. It is unclear how TG synthesis relates to LD formation and growth. Here, we identify two LD subpopulations: smaller LDs...

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Main Authors: Wilfling, Florian, Wang, Huajin, Haas, Joel T., Krahmer, Natalie, Gould, Travis J., Uchida, Aki, Cheng, Ji-Xin, Graham, Morven, Christiano, Romain, Fröhlich, Florian, Liu, Xinran, Buhman, Kimberly K., Coleman, Rosalind A., Bewersdorf, Joerg, Farese, Robert V., Walther, Tobias C.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727400/
https://ncbi.nlm.nih.gov/pubmed/23415954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.01.013
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