Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation

This study addresses how depletion of human cardiac left ventricle (LV) mitochondrial DNA (mtDNA) and epigenetic nuclear DNA methylation promote cardiac dysfunction in human dilated cardiomyopathy (DCM) through regulation of pyrimidine nucleotide kinases. Samples of DCM LV and right ventricle (n = 1...

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Detalhes bibliográficos
Main Authors: Koczor, Christopher A., Torres, Rebecca A., Fields, Earl J., Boyd, Amy, He, Stanley, Patel, Nilamkumar, Lee, Eva K., Samarel, Allen M., Lewis, William
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727015/
https://ncbi.nlm.nih.gov/pubmed/23695887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00014.2013
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