IL4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu in favor of TGF-β(1) to induce bronchial epithelial-mesenchymal transition (EMT)

Severe asthma is a chronic airway disease characterized by the Th2/Th17-polarized inflammation along with permanent airway remodeling. Despite past extensive studies, the exact role for Th2 and Th17 cytokines in asthmatic pathoetiology, particularly in the pathogenesis of bronchial epithelial-mesenc...

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Bibliographische Detailangaben
Hauptverfasser: Ji, Xiaoying, Li, Jinxiu, Xu, Li, Wang, Wenjing, Luo, Ming, Luo, Shuangling, Ma, Libing, Li, Keng, Gong, Subo, He, Long, Zhang, Zhijun, Yang, Ping, Zhou, Zhiguang, Xiang, Xudong, Wang, Cong-Yi
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2013
Schlagworte:
Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726963/
https://ncbi.nlm.nih.gov/pubmed/23923066
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