Myofiber prestretch magnitude determines regional systolic function during ectopic activation in the tachycardia-induced failing canine heart

Electrical dyssynchrony leads to prestretch in late-activated regions and alters the sequence of mechanical contraction, although prestretch and its mechanisms are not well defined in the failing heart. We hypothesized that in heart failure, fiber prestretch magnitude increases with the amount of ea...

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Detalhes bibliográficos
Main Authors: Howard, Elliot J., Kerckhoffs, Roy C. P., Vincent, Kevin P., Krishnamurthy, Adarsh, Villongco, Christopher T., Mulligan, Lawrence J., McCulloch, Andrew D., Omens, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Cardiac Excitation and Contraction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726954/
https://ncbi.nlm.nih.gov/pubmed/23666676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00186.2012
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