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tRNA Binding to Antitumor Drug Doxorubicin and Its Analogue
The binding sites of antitumor drug doxorubicin (DOX) and its analogue N-(trifluoroacetyl) doxorubicin (FDOX) with tRNA were located, using FTIR, CD, fluorescence spectroscopic methods and molecular modeling. Different binding sites are involved in drug-tRNA adducts with DOX located in the vicinity...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3726733/ https://ncbi.nlm.nih.gov/pubmed/23922696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069248 |
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