A common variant in the melatonin receptor gene (MTNR1B) is associated with increased risk of future type 2 diabetes and impaired early insulin secretion

Genome wide association studies revealed that variation in the Melatonin Receptor 1B gene (MTNR1B) is associated with insulin and glucose concentrations. Here we show that the risk genotype of this SNP predicts future type 2 diabetes (T2D) in two large prospective studies. Specifically, the risk gen...

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Detalhes bibliográficos
Main Authors: Lyssenko, Valeriya, Nagorny, Cecilia L.F., Erdos, Michael R., Wierup, Nils, Jonsson, Anna, Spégel, Peter, Bugliani, Marco, Saxena, Richa, Fex, Malin, Pulizzi, Nicolo, Isomaa, Bo, Tuomi, Tiinamaija, Nilsson, Peter, Kuusisto, Johanna, Tuomilehto, Jaakko, Boehnke, Michael, Altshuler, David, Sundler, Frank, Eriksson, Johan G., Jackson, Anne U., Laakso, Markku, Marchetti, Piero, Watanabe, Richard M., Mulder, Hindrik, Groop, Leif
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725650/
https://ncbi.nlm.nih.gov/pubmed/19060908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.288
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