A common variant in the melatonin receptor gene (MTNR1B) is associated with increased risk of future type 2 diabetes and impaired early insulin secretion

Genome wide association studies revealed that variation in the Melatonin Receptor 1B gene (MTNR1B) is associated with insulin and glucose concentrations. Here we show that the risk genotype of this SNP predicts future type 2 diabetes (T2D) in two large prospective studies. Specifically, the risk gen...

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Bibliografiset tiedot
Päätekijät: Lyssenko, Valeriya, Nagorny, Cecilia L.F., Erdos, Michael R., Wierup, Nils, Jonsson, Anna, Spégel, Peter, Bugliani, Marco, Saxena, Richa, Fex, Malin, Pulizzi, Nicolo, Isomaa, Bo, Tuomi, Tiinamaija, Nilsson, Peter, Kuusisto, Johanna, Tuomilehto, Jaakko, Boehnke, Michael, Altshuler, David, Sundler, Frank, Eriksson, Johan G., Jackson, Anne U., Laakso, Markku, Marchetti, Piero, Watanabe, Richard M., Mulder, Hindrik, Groop, Leif
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725650/
https://ncbi.nlm.nih.gov/pubmed/19060908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.288
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