Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy

The circadian clock gene Period2 (PER2) has been suggested to be a tumor suppressor. However, detailed mechanistic evidence has not been provided to support this hypothesis. We found that loss of PER2 enhanced invasion and activated expression of epithelial-mesenchymal transition (EMT) genes includi...

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Main Authors: Hwang-Verslues, Wendy W., Chang, Po-Hao, Jeng, Yung-Ming, Kuo, Wen-Hung, Chiang, Pei-Hsun, Chang, Yi-Cheng, Hsieh, Tsung-Han, Su, Fang-Yi, Lin, Liu-Chen, Abbondante, Serena, Yang, Cheng-Yuan, Hsu, Huan-Ming, Yu, Jyh-Cherng, Chang, King-Jen, Shew, Jin-Yuh, Lee, Eva Y.-H. P., Lee, Wen-Hwa
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725072/
https://ncbi.nlm.nih.gov/pubmed/23836662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222684110
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