Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest

BACKGROUND: Due to the functional defects in apoptosis signaling molecules or deficient activation of apoptosis pathways, leukemia has become an aggressive disease with poor prognosis. Although the majority of leukemia patients initially respond to chemotherapy, relapse is still the leading cause of...

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Autors principals: Kavitha, Chandagirikoppal V., Nambiar, Mridula, Narayanaswamy, Pavan B., Thomas, Elizabeth, Rathore, Ujjwal, Ananda Kumar, Channapillekoppalu S., Choudhary, Bibha, Rangappa, Kanchugarakoppal S., Raghavan, Sathees C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724874/
https://ncbi.nlm.nih.gov/pubmed/23922684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069103
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