Overexpressed DNA Polymerase Iota Regulated by JNK/c-Jun Contributes to Hypermutagenesis in Bladder Cancer

Human DNA polymerase iota (pol ι) possesses high error-prone DNA replication features and performs translesion DNA synthesis. It may be specialized and strictly regulated in normal mammalian cells. Dysregulation of pol ι may contribute to the acquisition of a mutator phenotype. However, there are fe...

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Detalhes bibliográficos
Main Authors: Yuan, Fang, Xu, Zhigang, Yang, Mingzhen, Wei, Quanfang, Zhang, Yi, Yu, Jin, Zhi, Yi, Liu, Yang, Chen, Zhiwen, Yang, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724822/
https://ncbi.nlm.nih.gov/pubmed/23922701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069317
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