STAT3 Signaling Induces the Differentiation of Human ICOS(+) CD4 T Cells Helping B lymphocytes

The generation of high-affinity antibodies and the development of B cell memory are dependent on the help provided by CD4 T cells. Mouse studies indicate that STAT3 signaling in CD4 T cells promotes the acquisition of the B cell help function. However, the role of STAT3 in humans has been controvers...

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Bibliographic Details
Main Authors: Ysebrant de Lendonck, Laure, Eddahri, Fouad, Delmarcelle, Yves, Nguyen, Muriel, Leo, Oberdan, Goriely, Stanislas, Marchant, Arnaud
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724802/
https://ncbi.nlm.nih.gov/pubmed/23923047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071029
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